Home » Science » Human Body Science » Off Label Use Of Recombinant Human Bone Morphogenetic Protein 2 RhBMP
Off Label Use Of Recombinant Human Bone Morphogenetic Protein 2 RhBMP
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Category : Science » Human Body Science
of recombinant human bone morphogenic protein-2 . human osteogenic protein 1 (rhOP-1) with xenogenic. bone mineral in a titanium scaffold. .
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Content Summary :
Purpose:
The off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the
treatment of mandibular bone defects was evaluated in 5 patients. The rhBMP-2 was used as an alternative
to autogenous bone grafting.
Patients and Methods:
A total of 5 patients had mandibular defects reconstructed with rhBMP-2, 1.5
mg/mL, soaked collagen sponges alone or in combination with bone marrow cells and allogenic
cancellous bone chips. Four of the patients had mandibular continuity defects and the fifth patient had
2 large bone cavities following removal of dentigerous cysts. Radiographs and clinical examinations were
used to evaluate healing. The longest patient follow-up was 22 months after reconstruction.
Results:
Radiographic and clinical assessments revealed bone regeneration and restoration of the
mandibular defects in 3 of the 5 patients. The rhBMP-2 failed in 2 patients with continuity defects. Both
patients with failed rhBMP-2 grafts were successfully repaired using autogenous harvested from the iliac
crest.
Conclusion:
Mandibular bone defects can be successfully reconstructed using rhBMP-2 soaked sponges
with and without including bone marrow cells and allogenic bone. Further studies are needed to
determine the ideal combination of components that will predictably and reliably regenerate bone in
different types of bone defects.
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