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Are Recombinant Human Bone Morphogenetic Protein 7 And Tobramycin

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Category : Science » Human Body Science

was reconstituted with 1 µg of recombinant human bone morphoge . composite of human bone morphogenetic protein (BMP) and autolyzed, .

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Content Summary : Objectives: To evaluate the effects of local antibiotics on bone mor- phogenetic protein-induced new bone formation in vivo. Design: In the research laboratory, inactive collagenous bone matrix was reconstituted with 1 µg of recombinant human bone morphoge- netic protein-7 and implanted subcutaneously in the thorax bilaterally in 30 male Long-Evans rats. Intervention: In group A (n = 2), the inactive collagenous bone matrix alone was implanted, bilaterally, and one of these pellets treated with either 500 µg tobramycin in aqueous solution or 3 to bramycin-impregnated polymethyl methacrylate beads. In group B (n = 4), the reconstituted pellets were not treated with tobramycin. In group C (n = 8), 1 reconstituted pellet in each rat was treated with 500 µg tobramycin in aqueous solution. In group D (n = 8), 3 tobramycin beads were placed in contact with 1 of the 2 reconstituted pellets in each rat. In group E (n = 8), 3 tobramycin beads were placed on the dorsal surface of 4 of the rats. All rats were killed on day 11.

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