Are Recombinant Human Bone Morphogenetic Protein 7 And Tobramycin
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was reconstituted with 1 µg of recombinant human bone morphoge . composite of human bone morphogenetic protein (BMP) and autolyzed, .
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Human Body Science
Content Summary :
Objectives:
To evaluate the effects of local antibiotics on bone mor-
phogenetic protein-induced new bone formation in vivo.
Design:
In the research laboratory, inactive collagenous bone matrix
was reconstituted with 1 µg of recombinant human bone morphoge-
netic protein-7 and implanted subcutaneously in the thorax bilaterally
in 30 male Long-Evans rats.
Intervention:
In group A (n = 2), the inactive collagenous bone
matrix alone was implanted, bilaterally, and one of these pellets
treated with either 500 µg tobramycin in aqueous solution or 3 to
bramycin-impregnated polymethyl methacrylate beads. In group B
(n = 4), the reconstituted pellets were not treated with tobramycin. In
group C (n = 8), 1 reconstituted pellet in each rat was treated with 500
µg tobramycin in aqueous solution. In group D (n = 8), 3 tobramycin
beads were placed in contact with 1 of the 2 reconstituted pellets in
each rat. In group E (n = 8), 3 tobramycin beads were placed on the
dorsal surface of 4 of the rats. All rats were killed on day 11.
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