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Practice Parameter Initiation Of Treatment For Parkinson Disease
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Category : Health » Parkinson Disease
. Parameter on medical treatment of Parkinson's disease (PD) concluded that levodopa . combined treatments after an average follow-up of 8.2 years. .
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Introduction Parkinson’s disease (PD) is a common neurodegenerative disorder with an estimated prevalence of 100 to-200/100,000 population. As it is a progressive disorder that results in significant disability 10 to15 years after onset, the financial and social burden of this disease is considerable, (1) particularly with our aging population. The worldwide cost of medications alone is estimated to be US $11 billion per year, with costs increasing three to five fold for patients with advanced disease. (2,3) Ideally, if a drug were available, initial treatment of PD should slow disease progression. Once symptomatic benefit is required, treatment should reduce disability without inducing complications over the long term. Based on these goals, there are several controversial questions regarding initial PD treatment. These include: Does selegiline have neuroprotective benefit in the treatment in early PD? What is the best agent to initiate specific dopaminergic therapy in early PD? Finally, is there a benefit of sustained-release levodopa over immediate release levodopa in the treatment of early PD?
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