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Parkinson Disease Diagnosis And Treatment
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primary treatment for symptomatic Parkinson's disease; . are effective treatments for these patients. 30. Nonpharmacologic Treatment .
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Early-Stage TreatmentEarly-stage Parkinson’s disease includes patients who have had the disease for less than five years or those who have not developed motor complications from levodopa use. 4 Treatment with monoamine oxidase-B (MAO-B) inhibitors, amantadine (Symmetrel), or anticholinergics may modestly improve mild symptoms; however, most patients need levodopa or a dopamine agonist. The American Academy of Neurology (AAN) recommends levodopa or a dopamine agonist, when dopaminergic treatment is required, depending on the need to improve motor disability (levodopa is better) or decrease motor complications (dopamine agonists cause fewer motor complications). 14 Table 3 15,16 summarizes medications approved for Parkinson’s disease. In general, a dopamine agonist is initiated in patients with mild disease with onset at a younger age, whereas levodopa is initiated for older patients with severe motor symptoms.
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