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There are three basic major types of peripheral nerves: sensory, motor and autonomic. These nerves stimulate sensory organs, the musculoskeletal system and internal organs. Sensory nerves serves as “sensors” of the environment, picking up signals or input from such organs as the eyes, ears, organs of taste and smell, mucous membranes covering or lining many tissues, and skin. These sensory messages are relayed to the brain for interpretation, integration, planning, and execution of subsequent actions. The motor system responds to these sensory stimuli and initiates voluntary/involuntary activity. Motor actions are mediated by motor nerves. Motor actions include such activities as blinking, swallowing, speaking, writing, standing, walking, running, etc. The autonomic system is another very important “noncentral” part of the nervous system and can be classified into the sympathetic, parasympathetic and gastrointestinal systems. The autonomic nervous system is the key to regulation of internal organ function. It controls vital functions of the lungs, cardiovascular system, gastrointestinal organs, and bladder and sexual function. Malfunction of any one or more parts of this system potentially can result in significant clinical symptoms of dysfunction. The types of abnormalities that can affect the peripheral or autonomic nervous systems in Sjogren’s syndrome patients are described below.