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Solbec Reports Progress In Phase I Trial In Patient With Advanced Cancer
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Category : Health » Mesothelioma Disease
treatment was to be assessed (the standard . treatments have failed. . clinical trials for the treatment of mesothelioma and malignant melanoma, and as .
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The first trial met its research objectives during the second half of 2004, with a safe and tolerable dose of 1mg/kg being identified. The protocol was amended in June 2004 to examine the same objectives while doubling the Coramsine™ infusion period to four hours. The purpose of this was to determine if the dose could be increased to allow therapeutic levels of Coramsine™ to be retained in the patient’s blood stream for a longer period than was seen in the previous trial. This could potentially provide treatment with greater therapeutic advantage. Preliminary results show that the trial has successfully reached its objectives and that Coramsine™ infused over a longer period (4 hours) is safe and tolerated at a level (1.5mg/kg) that is 50% greater than the 2 hour infusion.
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