Malignant Pleural Mesothelioma A Comprehensive Review
Category : Health » Mesothelioma Disease
Mesothelioma is an uncommon neoplasm arising from . diagnosis should be heightened. . and the diagnosis of mesothelioma. Lancet. 2003;362:1612-1616. .
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Mesothelioma Disease
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One disadvantage of VATS in mesothelioma is thepossible seeding of tumor along the surgical incisionsand chest tube tracts, which ultimately results in tumorgrowth in the chest wall in up to 20% of patients. 9 In addition to standard histology, special immuno- histochemical stains of the biopsy tissue may be neces-sary to make a definitive diagnosis of MPM because ofits histomorphologic similarities to adenocarcinoma.Mesothelioma is characterized by staining for calretininin 88% and vimentin in 50% of patients. However, ade-nocarcinoma usually lacks these markers and insteadstains positive for carcinoembryonic antigen (84%), CD15(77%) and Ber-EP-4 (82%). A complete array of immuno-stains must be performed to make a reliable diagnosis.Electron microscopy, although more costly, may be need-ed in equivocal cases to make the distinction betweenthe two neoplasms.
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