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Researchers Discover Mechanistic Link Between High Fat Diet And Type 2 Diabetes
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Category : Health » Diet Strategy
link between a high-fat, Western-style diet, and the onset of type 2 diabetes. In studies in mice, the scientists showed that a high-fat diet interferes with a .
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Researchers Discover MechanisticLink Between High-Fat Diet and Type2 Diabetes Howard Hughes Medical Institute researchers have discovered a molecularlink between a high-fat, Western-style diet, and the onset of type 2 diabetes.In studies in mice, the scientists showed that a high-fat diet interferes with agenetic mechanism they discovered that promotes insulin production,resulting in the classic signs of type 2 diabetes. In an article published in the December 29, 2005, issue of the journal Cell ,the researchers report that knocking out a single gene encoding the enzymeGnT-4a glycosyltransferase (GnT-4a ) disrupts insulin production.Importantly, the scientists showed that a high-fat diet suppresses the activityof GnT-4a and leads to type 2 diabetes due to failure of the pancreatic betacells.
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