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Current Approaches To Diagnosis And Treatment Of Celiac Disease An Evolving Spectrum
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Category : Health » Celiac Disease
Current Approaches to Diagnosis and Treatment of Celiac. Disease: An Evolving Spectrum . DIAGNOSIS AND TREATMENT OF CELIAC DISEASE 643
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Content Summary :
Celiac disease (CD) is a syndrome characterized by dam-age of the small intestinal mucosa caused by the gliadinfraction of wheat gluten and similar alcohol-soluble pro-teins (prolamines) of barley and rye in genetically sus-ceptible subjects. The presence of gluten in these sub-jects leads to self-perpetuating mucosal damage,whereas elimination of gluten results in full mucosalrecovery. The clinical manifestations of CD are proteanin nature and vary markedly with the age of the patient,the duration and extent of disease, and the presence ofextraintestinal pathologic conditions. In addition to theclassical gastrointestinal form, a variety of other clinicalmanifestations of the disease have been described, in-cluding atypical and asymptomatic forms. Therefore,diagnosis of CD is extremely challenging and relies on asensitive and specific algorithm that allows the identifi-cation of different manifestations of the disease. Sero-logic tests developed in the last decade provide a non-invasive tool to screen both individuals at risk for thedisease and the general population. However, the cur-rent gold standard for the diagnosis of CD remainshistologic confirmation of the intestinal damage in se-rologically positive individuals. The keystone treatmentof CD patients is a lifelong elimination diet in which foodproducts containing gluten are avoided.
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