Content Summary : What Really Causes Alzheimer’s Disease There is currently a global Alzheimer’s pandemic involving tensof millions of victims. In the USA alone, the number of thoseaffected is expected to reach 14 million by 2050. 1 This suffer- ing and the financial costs associated with it are unnecessary.Alzheimer’s disease is caused by aluminum and is particularlycommon in those carrying the APO E4 allele(s), who are moresusceptible to this toxic metal because they are less capablethan the general population of removing brain beta-amyloidand tau proteins. As a consequence, such individuals are athigher risk of developing Alzheimer’s disease, as these abnor-mal proteins build up in the brain and form neuritic plaquesand neurofibrillary tangles. Naturally, this process occurs moreoften and most rapidly in regions that promote the depositionof beta-amyloid and tau. Such “harmful” environments are thosein which drinking water is acidic, high in monomeric alumi-num, and lack magnesium, calcium, and silicic acid. Underthese circumstances, aluminum enters the brain and impairsvarious enzymes, including choline acetyltransferase, calcium/calmodulin kinase II, alkaline phosphatase, and phospholipaseA2. The result of this process is the abnormal brain pathologyseen in Alzheimer’s disease patients and the disrupted bio-chemistry associated with it. In an earlier publication, 2 I called this explanation of the downward spiral, known as Alzheimer’sdisease, Foster’s Multiple Antagonist Hypothesis.